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17 Hydroxyprogesterone

17 Hydroxyprogesterone

The 17-hydroxyprogesterone (17-OHP) test is an essential diagnostic tool used to measure the levels of 17-OHP in the blood, a precursor in cortisol production by the adrenal glands. This test is primarily used to screen for congenital adrenal hyperplasia (CAH), a genetic disorder that affects cortisol and aldosterone production, leading to increased androgen levels. Early detection through newborn screening programs is crucial for initiating treatment to prevent long-term complications. The test is also valuable for diagnosing CAH in older children and adults, particularly those with milder, late-onset forms. Additionally, it helps monitor treatment effectiveness in individuals diagnosed with CAH. The test involves a simple blood draw, with results indicating normal or elevated 17-OHP levels, which guide further diagnostic evaluations and treatment adjustments. While the 17-OHP test provides critical insights, it should be interpreted alongside other clinical findings to ensure accurate diagnosis and effective management of CAH.

Price of test:£86

The lowest price from the last 30 days: £86

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The 17-hydroxyprogesterone (17-OHP) test is essential for diagnosing congenital adrenal hyperplasia (CAH). It measures 17-OHP levels, a precursor in cortisol production, to identify adrenal gland dysfunction. Key objectives include:

- Screening Newborns: Early detection of CAH through routine newborn screening.
- Diagnosing Older Individuals: Identifying CAH in children and adults, especially late-onset forms.
- Monitoring Treatment: Evaluating treatment effectiveness by tracking 17-OHP levels.

Understanding test results helps in managing CAH symptoms and preventing complications.

Who Should Get Tested

The 17-hydroxyprogesterone (17-OHP) test is essential for diagnosing congenital adrenal hyperplasia (CAH), a genetic disorder affecting adrenal glands. This test measures 17-OHP levels, a precursor in cortisol production. Key uses include:

- Newborn Screening: Early detection of CAH to prevent complications.
- Diagnosis in Older Individuals: Identifies late-onset CAH in children and adults.
- Monitoring Treatment: Ensures treatment effectiveness by tracking 17-OHP levels.

Performed via a blood sample, the test requires informing healthcare providers about medications to avoid interference. Elevated 17-OHP levels suggest CAH, necessitating further evaluation.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results is crucial for managing congenital adrenal hyperplasia (CAH). Here's a brief guide:

- Normal Levels: Vary by age and sex. Newborns: <400-600 ng/dL; Prepubescent children: <100 ng/dL; Adults: <200 ng/dL.
- Elevated Levels: Suggest CAH. Infants: 2,000-40,000 ng/dL; Adults: >200 ng/dL may indicate nonclassical adrenal hyperplasia.
- Follow-Up: Additional tests like plasma renin activity or ACTH may be needed for confirmation.
- Interpretation: Results should be considered alongside clinical findings for accurate diagnosis and treatment planning.

Price of test:£86

The lowest price from the last 30 days: £86

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