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Adrenocorticotropic Hormone (ACTH)

Adrenocorticotropic Hormone (ACTH)

The Adrenocorticotropic Hormone (ACTH) test is an essential diagnostic procedure used to assess the functionality of the pituitary and adrenal glands. This blood test measures ACTH levels, a hormone produced by the pituitary gland, crucial for regulating cortisol production by the adrenal glands. ACTH, or corticotropin, is a peptide hormone integral to the hypothalamic-pituitary-adrenal (HPA) axis, a feedback system managing the body's stress response. The test primarily aids in diagnosing and monitoring conditions affecting cortisol levels, such as Cushing's and Addison's diseases. Conducted by drawing a blood sample, typically in the morning when cortisol peaks, the test requires specific preparations like avoiding steroids and fasting. Normal ACTH levels range from 10 to 60 pg/mL, with deviations indicating potential disorders. Abnormal results may necessitate further testing, such as ACTH stimulation or dexamethasone suppression tests. While generally safe, the test carries minor risks like bruising or dizziness.

Price of test:£140

The lowest price from the last 30 days: £140

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The ACTH test is essential for evaluating pituitary and adrenal gland function. It measures ACTH levels, crucial for cortisol regulation. Key objectives include:

- Diagnosing disorders like Cushing's and Addison's disease.
- Monitoring pituitary gland ACTH production.
- Assessing adrenal response to ACTH.

Preparation involves:

- Avoiding steroids and certain foods.
- Ensuring adequate sleep and stress reduction.

Normal ACTH levels range from 10 to 60 pg/mL. Abnormal results may indicate:

- High ACTH: Possible Cushing's disease.
- Low ACTH: Potential hypopituitarism or Addison's disease.

Additional tests may be required for confirmation.

Who Should Get Tested

The ACTH test is essential for diagnosing and monitoring conditions affecting cortisol levels. It is particularly important for individuals with symptoms suggesting disorders of the pituitary or adrenal glands. Key candidates for testing include:

- Suspected Cushing's Disease: Patients with symptoms like weight gain, high blood pressure, and skin changes.
- Suspected Addison's Disease: Individuals experiencing fatigue, weight loss, and low blood pressure.
- Unexplained Hormonal Imbalances: Those with abnormal cortisol levels needing further investigation.
- Monitoring Known Conditions: Patients with diagnosed endocrine disorders requiring ongoing assessment.

This test aids in understanding hormone regulation and guides treatment strategies.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results is crucial for interpreting the ACTH test, which evaluates pituitary and adrenal gland function. Here's a brief guide:

- Normal Range: ACTH levels typically range from 10 to 60 pg/mL in adults.
- High ACTH Levels: May indicate Cushing's disease or other conditions like multiple endocrine neoplasia.
- Low ACTH Levels: Could suggest hypopituitarism or Addison's disease.

Abnormal results often necessitate further testing, such as ACTH stimulation or dexamethasone suppression tests, to pinpoint the underlying cause and guide treatment.

Price of test:£140

The lowest price from the last 30 days: £140

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