Anti DNA

The anti-double-stranded DNA (anti-dsDNA) antibody test is an essential diagnostic tool for systemic lupus erythematosus (SLE), an autoimmune disorder where the immune system attacks the body's tissues. This test identifies antibodies that specifically target double-stranded DNA, serving as a highly specific marker for SLE. Conducted via enzyme-linked immunosorbent assay (ELISA), the test involves collecting a blood sample, which is then exposed to double-stranded DNA antigens. If anti-dsDNA antibodies are present, they bind to these antigens, and an enzyme-induced color change indicates their presence. The test results are interpreted based on antibody levels: low levels may suggest minimal lupus activity, moderate levels could indicate other autoimmune conditions, and high levels are typically associated with active SLE, especially lupus nephritis. While the test is specific for SLE, it is not used to monitor disease activity over time and should be interpreted alongside clinical symptoms and other diagnostic tests for accurate diagnosis and management.

Price of test:£59

The lowest price from the last 30 days: £59

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The anti-dsDNA antibody test is vital for diagnosing and monitoring systemic lupus erythematosus (SLE). It identifies antibodies targeting double-stranded DNA, specific markers for SLE. The test involves:

- Blood Sample Collection: Obtain a sample from the patient.
- Antigen Preparation: Introduce the sample to DNA antigens.
- Antibody Binding: Detect binding of antibodies to antigens.
- Enzyme Addition: Add enzyme to reveal binding through color change.
- Color Change Detection: Measure color change to assess antibody levels.

Results guide diagnosis but not disease activity monitoring, requiring clinical correlation.

Who Should Get Tested

The anti-double-stranded DNA (anti-dsDNA) antibody test is vital for diagnosing systemic lupus erythematosus (SLE). It identifies antibodies targeting double-stranded DNA, specific markers for SLE. Here's who should be tested:

- Suspected SLE Patients: Individuals showing symptoms like joint pain, skin rashes, or kidney issues.
- Monitoring SLE Activity: Patients with a confirmed SLE diagnosis to assess disease progression.
- Differential Diagnosis: Those with symptoms overlapping other autoimmune diseases, such as Sjogren syndrome or mixed connective tissue disease.
- High ANA Levels: Patients with elevated anti-nuclear antibodies needing further evaluation.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for the anti-dsDNA antibody test is crucial for diagnosing and managing systemic lupus erythematosus (SLE). This test detects antibodies targeting double-stranded DNA, specific markers for SLE. Here's a brief overview:

- Low Levels: May suggest minimal lupus activity but don't rule out lupus nephritis.
- Moderate Levels: Could indicate other autoimmune diseases like Sjogren syndrome.
- High Levels: Typically found in active SLE, especially with lupus nephritis.

While highly specific, results should be considered alongside clinical symptoms and other tests for accurate diagnosis and management.

Price of test:£59

The lowest price from the last 30 days: £59

AI-Powered Insights and Expert Validation

Advanced AI Interpretation

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Language Model and Trusted Sources

At the core of Diagu's AI system is an advanced language model, engineered to transform complex medical data into clear, comprehensible, and informative descriptions. This model is adept at articulating detailed test analyses in a way that is accessible to both healthcare professionals and patients. The model's development involved the meticulous processing of high-quality sources, including reputable medical websites, renowned medical textbooks, and peer-reviewed research papers. This ensures that the language used in test descriptions is not only accurate and informative but also up-to-date with the latest medical findings and trends. By leveraging this rich tapestry of trusted sources, our AI system provides a deeper understanding of each test, fostering informed decision-making and enhanced patient care.

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