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Anti Sc1 70
The Scl-70 antibody test is an essential diagnostic tool for identifying systemic sclerosis (SSc), or scleroderma, an autoimmune disease marked by collagen deposition in the skin and organs, causing fibrosis and vasculopathy. Scl-70 antibodies target DNA topoisomerase I, an enzyme found in cell cytoplasm and nucleoli, indicating an immune response typical of SSc. This test is crucial for differentiating SSc from other connective tissue diseases like systemic lupus erythematosus (SLE). It is particularly useful for identifying SSc patients at risk for diffuse cutaneous involvement and interstitial lung disease. Conducted using solid-phase immunoassays such as ELISA, the test detects Scl-70 antibodies through fluorescent or enzymatic markers. A positive result supports an SSc diagnosis, but low positives require careful interpretation due to potential cross-reactivity. The test's results should be considered alongside other clinical findings and laboratory tests to ensure accurate diagnosis and prognosis assessment.
The Scl-70 antibody test is an essential diagnostic tool for identifying systemic sclerosis (SSc), or scleroderma, an autoimmune disease marked by collagen deposition in the skin and organs, causing fibrosis and vasculopathy. Scl-70 antibodies target DNA topoisomerase I, an enzyme found in cell cytoplasm and nucleoli, indicating an immune response typical of SSc. This test is crucial for differentiating SSc from other connective tissue diseases like systemic lupus erythematosus (SLE). It is particularly useful for identifying SSc patients at risk for diffuse cutaneous involvement and interstitial lung disease. Conducted using solid-phase immunoassays such as ELISA, the test detects Scl-70 antibodies through fluorescent or enzymatic markers. A positive result supports an SSc diagnosis, but low positives require careful interpretation due to potential cross-reactivity. The test's results should be considered alongside other clinical findings and laboratory tests to ensure accurate diagnosis and prognosis assessment.
The lowest price from the last 30 days: £104
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One day
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The Scl-70 antibody test is essential for diagnosing systemic sclerosis (SSc), aiding in distinguishing it from other connective tissue diseases. Key points include:
- Clinical Utility: Differentiates SSc from conditions like systemic lupus erythematosus (SLE).
- Methodology: Utilizes solid-phase immunoassays such as ELISA.
- Interpretation: Positive results suggest SSc; caution with low positives due to cross-reactivity.
- Specimen Requirements: Serum needed; specific storage conditions apply.
- Turnaround Time: Typically 1 to 3 days.
- Cautions: Clinical correlation is crucial for accurate diagnosis.
The Scl-70 antibody test is essential for diagnosing systemic sclerosis (SSc). It identifies autoantibodies targeting DNA topoisomerase I, aiding in distinguishing SSc from other connective tissue diseases. Key points include:
- Clinical Utility: Helps identify SSc patients at risk for severe complications.
- Methodology: Uses solid-phase immunoassays like ELISA.
- Interpretation: Positive results suggest SSc but require clinical context.
- Specimen Requirements: Serum needed; specific storage conditions apply.
- Cautions: Low positives may indicate other conditions; cross-reactivity possible.
This test is crucial for diagnosis and prognosis, but careful interpretation is necessary.
Understanding test results for the Scl-70 antibody test is essential for accurate diagnosis and management of systemic sclerosis (SSc). Here’s a brief guide:
- Positive Result: Indicates a strong likelihood of SSc, especially in the right clinical context.
- Low Positive Result: Requires careful interpretation; may appear in other inflammatory conditions.
- Clinical Correlation: Combine results with other tests and clinical findings for a comprehensive diagnosis.
- Specimen Handling: Ensure proper collection and storage to avoid rejection.
- Turnaround Time: Typically 1-3 days, but may vary.
Understanding these aspects aids in effective patient care and disease management.
The lowest price from the last 30 days: £104
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