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Carboxyhaemoglobin

The Anticardiolipin IgG test is a laboratory examination used to detect IgG antibodies targeting cardiolipin, a component of cell membranes and platelets. These antibodies are part of antiphospholipid antibodies, linked to autoimmune conditions like antiphospholipid syndrome (APS). The test primarily aids in diagnosing and monitoring APS, a condition marked by increased risk of blood clots, recurrent pregnancy loss, and other complications. Conducted via enzyme-linked immunosorbent assay (ELISA), the test measures antibody levels by detecting their binding to cardiolipin antigens on a microtiter plate. Results are expressed in GPL units, with higher titers indicating a greater risk of thrombotic events. High IgG anticardiolipin antibody levels are associated with arterial and venous thrombosis, stroke, and myocardial infarction. For APS diagnosis, antibodies must be detected on two occasions, six weeks apart. Management often involves anticoagulant therapy to prevent clots while minimizing bleeding risks.

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Price of test:£174

The lowest price from the last 30 days: £174

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Awaiting result:

One day

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Collect material:

Blood

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Purpose of the test

The Anticardiolipin IgG test is essential for diagnosing and monitoring antiphospholipid syndrome (APS). It detects IgG antibodies targeting cardiolipin, aiding in identifying individuals at risk for thrombotic events. Key points include:

- Purpose: Diagnose APS, assess thrombotic risk.
- Method: ELISA detects IgG binding to cardiolipin.
- Results Interpretation:
- Negative: <15 GPL units.
- Indeterminate: 15-20 GPL units.
- Low to Moderately Positive: 20-80 GPL units.
- High Positive: >80 GPL units.
- Clinical Significance: High titers linked to thrombosis, pregnancy loss.
- Management: Anticoagulant therapy for high-risk patients.

Who Should Get Tested

The Anticardiolipin IgG test is essential for diagnosing antiphospholipid syndrome (APS), a condition linked to blood clots and pregnancy complications. Key candidates for testing include:

- Individuals with unexplained blood clots.
- Patients experiencing recurrent pregnancy loss.
- Those with systemic lupus erythematosus (SLE) showing thrombotic symptoms.

The test uses ELISA to detect IgG antibodies targeting cardiolipin. Results guide APS management, often involving anticoagulant therapy. High antibody titers indicate increased thrombotic risk, necessitating careful interpretation and follow-up testing to confirm persistent antibody presence.

Blood Test Preparation Guidelines
Time of day
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It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.
Fasting
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It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.
Stay hydrated
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Drinking water prior to testing can help with sample collection.
Other factors
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Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.
Medications and supplements:
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Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.
Biotin supplements:
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High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.
Interpreting Test Results

Understanding test results for the Anticardiolipin IgG test is crucial for diagnosing and managing antiphospholipid syndrome (APS). This test detects IgG antibodies targeting cardiolipin, indicating potential thrombotic risks. Results are measured in GPL units:

- Negative: <15 GPL
- Indeterminate: 15-20 GPL
- Low to Moderately Positive: 20-80 GPL
- High Positive: >80 GPL

High titers suggest increased risks of thrombosis and pregnancy complications. Persistent antibody presence, confirmed over six weeks, supports APS diagnosis. Accurate interpretation guides effective management, often involving anticoagulant therapy.

Price of test:£174

The lowest price from the last 30 days: £174

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