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Apolipoprotein A

Apolipoprotein A

Apolipoprotein A1 (ApoA1) is a key protein linked to high-density lipoprotein (HDL), often termed "good" cholesterol, playing a vital role in reverse cholesterol transport. This process involves removing excess cholesterol from tissues and transporting it to the liver for excretion. Measuring ApoA1 levels in the blood is an important diagnostic tool for assessing cardiovascular health and risk. High ApoA1 levels are inversely related to the risk of atherosclerotic cardiovascular disease (ASCVD), indicating a reduced risk of coronary artery disease (CAD). Unlike HDL cholesterol alone, ApoA1 provides unique clinical insights, being more sensitive in detecting early atherosclerotic changes. The test requires a serum or plasma specimen, typically collected in a red-top or gel-barrier tube. ApoA1 levels are measured using an automated turbidimetric immunoassay. Reference values vary by age and sex, with low levels indicating increased ASCVD risk. Proper preparation and understanding of influencing factors are essential for accurate results.

Price of test:£92

The lowest price from the last 30 days: £92

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

Apolipoprotein A1 (ApoA1) is integral to cardiovascular health assessment. It plays a key role in reverse cholesterol transport, aiding in cholesterol removal from tissues. Measuring ApoA1 levels helps evaluate atherosclerotic cardiovascular disease (ASCVD) risk. Key points include:

- Purpose: Assess ASCVD risk; high ApoA1 levels indicate reduced coronary artery disease risk.
- Clinical Significance: More sensitive than HDL-C for early atherosclerosis detection.
- Specimen Requirements: Serum or plasma; 0.5 mL volume.
- Methodology: Automated turbidimetric immunoassay.
- Reference Values: Vary by age and sex; ≥120 mg/dL for males, ≥140 mg/dL for females over 18.
- Preparation: 12-14 hour fasting recommended.

Who Should Get Tested

Apolipoprotein A1 (ApoA1) testing is essential for individuals at risk of cardiovascular disease. Key groups include:

- Individuals with a family history of heart disease: Early detection can guide preventive measures.
- Patients with existing cardiovascular conditions: Monitoring ApoA1 levels helps assess treatment efficacy.
- Those on statin therapy: Increased ApoA1 levels indicate reduced cardiovascular events.
- Individuals with low HDL-C levels: ApoA1 provides additional insights beyond traditional lipid profiles.
- Patients with genetic disorders like Tangier disease: Low ApoA1 levels aid in diagnosis.

Understanding ApoA1 levels enhances cardiovascular risk assessment and management.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for Apolipoprotein A1 (ApoA1) is essential for evaluating cardiovascular health. Key points include:

- Purpose: Assess risk for atherosclerotic cardiovascular disease (ASCVD).
- Clinical Significance: High ApoA1 levels indicate reduced heart disease risk.
- Specimen Requirements: Serum or plasma, 0.5 mL, stored appropriately.
- Methodology: Automated turbidimetric immunoassay.
- Reference Values: Vary by age and sex; ≥120 mg/dL for males >18, ≥140 mg/dL for females >18.
- Interpretation: Low levels suggest increased ASCVD risk.
- Preparation: 12-14 hour fasting recommended.

Price of test:£92

The lowest price from the last 30 days: £92

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