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The C1 esterase inhibitor (C1-INH) test is an essential diagnostic tool used to assess the levels of C1-INH protein in the blood, crucial for regulating the complement system within the innate immune system. This system, comprising numerous proteins, helps protect the body from infections and other threats. The test is primarily used to diagnose hereditary angioedema (HAE), a genetic disorder causing severe swelling in various body parts, potentially leading to life-threatening complications. Conducted by drawing a blood sample, the test requires no special preparation, although fasting is preferred for accuracy. Normal C1-INH levels range from 16 to 33 mg/dL, but variations can occur. Abnormal results may indicate hereditary or acquired angioedema, infections, or other conditions. While the test carries minimal risks, such as bleeding or infection at the puncture site, it is crucial for diagnosing and monitoring treatment effectiveness in patients with immune-related disorders, ensuring timely and appropriate care.

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Price of test:£34

The lowest price from the last 30 days: £34

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Awaiting result:

One day

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Collect material:

Blood

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Prepare:

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Purpose of the test

The C1 esterase inhibitor (C1-INH) test is essential for diagnosing and monitoring conditions linked to low protein levels in the blood. It plays a crucial role in the complement system, part of the innate immune system, which protects the body from infections and neutralizes foreign substances. Key points include:

- Purpose: Diagnoses hereditary angioedema (HAE), characterized by severe swelling.
- Procedure: Blood sample drawn, serum frozen within 30 minutes.
- Results: Normal levels range from 16 to 33 mg/dL; abnormalities indicate potential disorders.
- Risks: Minimal, including bleeding and infection.
- Monitoring: Assesses treatment effectiveness for conditions like HAE.

Who Should Get Tested

The C1 esterase inhibitor (C1-INH) test is essential for diagnosing conditions linked to low protein levels in the blood. It plays a crucial role in the complement system, part of the innate immune system. Key points include:

- Purpose: Diagnoses hereditary angioedema (HAE), a genetic disorder causing severe swelling.
- Procedure: Involves a blood sample, requiring no special preparation.
- Results: Normal levels range from 16 to 33 mg/dL. Abnormal levels indicate potential disorders.
- Risks: Minimal, including bleeding or infection.
- Monitoring: Helps adjust treatment for optimal management of HAE.

Blood Test Preparation Guidelines
Time of day
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It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.
Fasting
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It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.
Stay hydrated
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Drinking water prior to testing can help with sample collection.
Other factors
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Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.
Medications and supplements:
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Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.
Biotin supplements:
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High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.
Interpreting Test Results

Understanding test results for the C1 esterase inhibitor (C1-INH) test is crucial for diagnosing and managing immune-related disorders. Here's a brief overview:

- Normal Results: C1-INH levels typically range from 16 to 33 mg/dL. Functional activity is also assessed.
- Abnormal Results: Low levels may indicate hereditary angioedema, while high levels could suggest infections or malnutrition.
- Risks: Minimal, including bleeding or infection at the puncture site.
- Monitoring: Essential for adjusting treatment, especially in hereditary angioedema cases.

This test aids in ensuring effective patient care.

Price of test:£34

The lowest price from the last 30 days: £34

AI-Powered Insights and Expert Validation
Advanced AI Interpretation
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