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Chromogranin (CgA)

Chromogranin (CgA)

The CH50 blood test is a vital diagnostic tool that evaluates the total functional activity of the complement system, a network of proteins crucial for immune response. This test measures the classical pathway's activity, involving complement components C1 through C9, to ensure they are present and functioning correctly. A blood sample is collected via venipuncture, allowed to clot, and then the serum is separated and frozen for analysis. The CH50 test is often ordered to assess complement component deficiencies, immune complex diseases like systemic lupus erythematosus, rheumatoid arthritis, glomerulonephritis, cryoglobulinemia, and certain infectious diseases. Normal CH50 levels indicate a well-functioning complement system, while abnormal results can suggest various conditions, including autoimmune diseases and infections. Despite slight risks associated with blood draws, the CH50 test provides critical insights into immune function, aiding in diagnosing and managing immune-related disorders and monitoring treatment effectiveness.

Price of test:£164

The lowest price from the last 30 days: £164

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The CH50 blood test evaluates the complement system's functional activity, crucial for immune response. It measures the classical pathway's components, C1 to C9, ensuring they function correctly. Reasons for ordering the test include:

- Complement Component Deficiency: Identifies deficiencies leading to infections or autoimmune diseases.
- Immune Complex Diseases: Assesses activity in conditions like systemic lupus erythematosus.
- Rheumatoid Arthritis and Glomerulonephritis: Evaluates complement activity in inflammatory conditions.
- Cryoglobulinemia: Diagnoses and manages abnormal protein conditions.
- Infectious Diseases: Evaluates complement activity in infections like meningitis.

Normal results vary, while abnormal results indicate various conditions.

Who Should Get Tested

Chromogranin A (CgA) is vital for diagnosing and monitoring neuroendocrine tumors. It is secreted by neuroendocrine cells found in various body tissues. CgA helps form secretory granules, ensuring regulated hormone release. Key points include:

- Diagnostic Marker: Useful for detecting neuroendocrine neoplasms like carcinoids and pheochromocytomas.
- Monitoring: Changes in CgA levels indicate tumor progression.
- Interpretation: Elevated CgA can occur in other conditions; PPIs may cause false positives.
- Patient Preparation: Fasting and stopping PPIs improve test specificity.

CgA testing, combined with clinical evidence, aids in effective tumor management.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for the CH50 blood test is crucial for interpreting the functional activity of the complement system. This test evaluates the classical pathway, providing insights into immune response and potential deficiencies. Key points include:

- Normal Results: Typically range from 41 to 90 hemolytic units.
- Abnormal Results: May indicate increased activity in conditions like cancer or decreased activity in diseases such as lupus.
- Clinical Applications: Essential for diagnosing immune-related disorders and monitoring treatment effectiveness.

Understanding these results aids in managing conditions like SLE and rheumatoid arthritis effectively.

Price of test:£164

The lowest price from the last 30 days: £164

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