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CFTR Gene Analysis
Chromogranin A (CgA) is a vital protein used in diagnosing and monitoring neuroendocrine tumors. Secreted by neuroendocrine cells, CgA is part of the granin family, playing a key role in hormone and neurotransmitter regulation. It is found in secretory granules, aiding in the controlled release of signaling molecules essential for physiological functions. Clinically, CgA serves as a diagnostic marker for neuroendocrine neoplasms like carcinoids and pheochromocytomas, and helps detect residual or recurrent disease. Elevated CgA levels often indicate tumor progression, especially in gastroenteropancreatic neuroendocrine tumors. However, interpretation requires caution due to potential false positives from conditions like gastrointestinal disorders or proton pump inhibitor therapy. Accurate results depend on patient preparation, including fasting and discontinuing PPIs. While not a standalone test, CgA provides crucial insights when combined with clinical symptoms and other diagnostics, aiding in effective management of neuroendocrine tumors.
Chromogranin A (CgA) is a vital protein used in diagnosing and monitoring neuroendocrine tumors. Secreted by neuroendocrine cells, CgA is part of the granin family, playing a key role in hormone and neurotransmitter regulation. It is found in secretory granules, aiding in the controlled release of signaling molecules essential for physiological functions. Clinically, CgA serves as a diagnostic marker for neuroendocrine neoplasms like carcinoids and pheochromocytomas, and helps detect residual or recurrent disease. Elevated CgA levels often indicate tumor progression, especially in gastroenteropancreatic neuroendocrine tumors. However, interpretation requires caution due to potential false positives from conditions like gastrointestinal disorders or proton pump inhibitor therapy. Accurate results depend on patient preparation, including fasting and discontinuing PPIs. While not a standalone test, CgA provides crucial insights when combined with clinical symptoms and other diagnostics, aiding in effective management of neuroendocrine tumors.
The lowest price from the last 30 days: £626
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One day
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Blood
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Chromogranin A (CgA) is vital for diagnosing and monitoring neuroendocrine tumors. This protein, secreted by neuroendocrine cells, aids in hormone and neurotransmitter regulation. Key points include:
- Diagnostic Marker: Useful for identifying neuroendocrine neoplasms like carcinoids and pheochromocytomas.
- Monitoring: Tracks tumor progression in gastroenteropancreatic neuroendocrine tumors.
- Test Interpretation: Elevated levels may indicate various conditions; false positives can occur with proton pump inhibitors.
- Specimen Handling: Requires serum, with specific collection and storage protocols.
- Patient Preparation: Fasting and stopping PPIs enhance test accuracy.
CgA testing, while not standalone, is crucial when combined with clinical assessments.
The CFTR Gene Analysis is essential for diagnosing cystic fibrosis and related conditions. It is particularly beneficial for:
- Individuals with a clinical diagnosis of CF.
- Those with atypical presentations, like congenital bilateral absence of the vas deferens or pancreatitis.
- People with low detection rates by targeted variant analysis due to their ancestral background.
The test uses next-generation sequencing to identify various genetic variants, aiding in diagnosis, prognosis, and clinical management. It also supports recurrence risk assessment, familial screening, and genetic counseling, ensuring comprehensive care and informed decision-making.
Understanding test results for Chromogranin A (CgA) is crucial in diagnosing and monitoring neuroendocrine tumors. Here are key points to consider:
- CgA Levels: Elevated levels may indicate neuroendocrine tumors but can also be seen in other conditions.
- False Positives: Proton pump inhibitors can cause false positives; discontinue use 14 days before testing.
- Hook Effect: Extremely high CgA levels may lead to inaccurate results; retesting might be necessary.
- Clinical Correlation: Always interpret results alongside clinical symptoms and other diagnostic tests.
- Patient Preparation: Fasting and stopping PPIs enhance test accuracy.
The lowest price from the last 30 days: £626
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