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Factor V of Leiden

Factor V of Leiden

The Glutamic Acid Decarboxylase (GAD) antibody test is a semi-quantitative enzyme-linked immunosorbent assay (ELISA) designed to detect antibodies against the GAD65 isoform in human serum or cerebrospinal fluid (CSF). This test is pivotal in diagnosing and managing autoimmune conditions, particularly type 1 diabetes mellitus (T1DM) and certain neurological disorders. In T1DM, the immune system attacks insulin-producing cells in the pancreas, and the presence of GAD65 antibodies serves as a reliable marker for this condition. The test also helps differentiate between type 1 and type 2 diabetes, guiding appropriate treatment strategies. Beyond diabetes, high levels of GAD65 antibodies are associated with neurological disorders like stiff-person syndrome, characterized by muscle rigidity and spasms. The test involves measuring antibody levels in serum or CSF, with specific thresholds indicating positivity. Its results are crucial for diagnosing autoimmune conditions and monitoring treatment responses, making it an essential tool in clinical practice.

Price of test:£348

The lowest price from the last 30 days: £348

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The GAD antibody test is a semi-quantitative ELISA used to detect antibodies against GAD65 in serum or CSF, crucial for diagnosing autoimmune conditions.

- Purpose: Assesses susceptibility to type 1 diabetes and distinguishes it from type 2 diabetes.
- Neurological Role: Identifies conditions like stiff-person syndrome.
- Specimen: Requires 1 mL serum or CSF; stability varies by storage.
- Methodology: Uses recombinant GAD65 antigen in ELISA.
- Interpretation: High titers indicate autoimmune disorders.
- Clinical Implications: Guides diagnosis and management of autoimmune diseases.

Who Should Get Tested

Factor V Leiden testing is crucial for identifying individuals at risk of blood clotting disorders. Those who should consider testing include:

- Individuals with a personal or family history of venous thromboembolism (VTE).
- People who have experienced deep vein thrombosis (DVT) or pulmonary embolism (PE).
- Women with recurrent miscarriages or complications during pregnancy.
- Individuals with a family history of Factor V Leiden.

Early diagnosis through genetic testing can guide treatment and lifestyle changes, reducing the risk of life-threatening complications.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results is crucial for effective diagnosis and management. The GAD antibody test provides insights into autoimmune conditions affecting the pancreas and nervous system. Key points include:

- Purpose: Identifies susceptibility to type 1 diabetes and distinguishes it from type 2 diabetes.
- Neurological Relevance: Detects antibodies linked to disorders like stiff-person syndrome.
- Diagnostic Criteria: Serum or CSF levels above 5.0 IU/mL indicate positivity.
- Specimen Handling: Proper storage is essential; serum can be refrigerated or frozen, while CSF must be frozen.
- Interpretation: High antibody levels suggest autoimmune disorders; low levels are common in type 1 diabetes.

Price of test:£348

The lowest price from the last 30 days: £348

AI-Powered Insights and Expert Validation

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