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Plasma Viscosity

The HLA DQ2/DQ8 lab test is a genetic analysis designed to assess an individual's risk for celiac disease, an autoimmune disorder triggered by gluten consumption that damages the small intestine. This test identifies specific genetic markers, particularly the HLA-DQ2 and HLA-DQ8 alleles, which are strongly associated with celiac disease. Approximately 90% of celiac patients carry the HLA-DQ2 haplotype, while 5-10% have the HLA-DQ8 haplotype. The test involves extracting DNA from a blood sample and using real-time PCR technology to detect the presence of these alleles. Results can indicate a genetic predisposition to celiac disease, with a significantly higher risk for those carrying these haplotypes. However, the presence of these genetic markers alone does not confirm the disease, as other genetic and environmental factors also contribute. The test is valuable for ruling out celiac disease in individuals without these haplotypes and aids in tailoring diagnostic and treatment strategies.

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Price of test:£97

The lowest price from the last 30 days: £97

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Awaiting result:

One day

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Collect material:

Blood

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Prepare:

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Purpose of the test

The HLA DQ2/DQ8 lab test is a genetic analysis used to assess the risk of celiac disease by identifying specific genetic markers. This test focuses on detecting HLA-DQ2 and HLA-DQ8 alleles, which are strongly associated with celiac disease.

- DNA Extraction: Blood sample DNA is extracted.
- PCR Amplification: DNA is amplified to generate specific sequences.
- Probe Hybridization: TaqMan probes bind to DQA1 and DQB1 alleles.
- Detection: Presence of probes indicates specific alleles.
- Result Interpretation: Determines presence or absence of DQ2/DQ8 haplotypes.

Understanding these markers aids in managing celiac disease risk.

Who Should Get Tested

Plasma viscosity testing is essential for individuals with conditions that affect plasma protein levels. Key groups who should be tested include:

- Patients with Inflammatory Diseases: Conditions like rheumatoid arthritis often elevate plasma viscosity. Regular testing helps monitor disease severity and treatment efficacy.

- Individuals with Malignant Disorders: Diseases such as multiple myeloma can cause significant increases in plasma viscosity due to paraprotein secretion.

- Those with Hyperviscosity Syndrome: Monitoring is crucial for managing symptoms and treatment response, particularly in cases involving IgM monoclonal proteins.

This test is invaluable for assessing acute phase responses and ensuring effective clinical management.

Blood Test Preparation Guidelines
Time of day
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It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.
Fasting
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It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.
Stay hydrated
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Drinking water prior to testing can help with sample collection.
Other factors
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Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.
Medications and supplements:
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Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.
Biotin supplements:
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High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.
Interpreting Test Results

Understanding test results from the HLA DQ2/DQ8 lab test is crucial for assessing genetic risk for celiac disease. Here's a brief guide:

- Negative Result: Absence of DQ2/DQ8 haplotypes suggests a low likelihood of developing celiac disease.
- Positive Result: Presence of DQ2 and/or DQ8 indicates a genetic predisposition, increasing risk significantly.
- Half DQ2: Detection of only one allele (HLA-DQA1*05 or HLA-DQB1*02) suggests a lower, yet elevated risk.

While these results highlight genetic risk, they don't confirm celiac disease, necessitating further clinical evaluation.

Price of test:£97

The lowest price from the last 30 days: £97

AI-Powered Insights and Expert Validation
Advanced AI Interpretation
Diagu's AI system represents a breakthrough in medical test analysis, employing state-of-the-art algorithms meticulously trained on a vast spectrum of authoritative medical literature and data. This system intricately analyses laboratory test results, extracting nuanced insights that might elude conventional methods. Our AI delves into complex interrelations between various health markers, offering a comprehensive understanding that supports accurate diagnosis and effective treatment planning. The foundation of our AI's analytical prowess lies in its extensive training, encompassing data from globally recognised medical journals, trusted healthcare databases, and breakthrough scientific studies. This ensures that every analysis is grounded in the latest and most comprehensive medical knowledge.
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At the core of Diagu's AI system is an advanced language model, engineered to transform complex medical data into clear, comprehensible, and informative descriptions. This model is adept at articulating detailed test analyses in a way that is accessible to both healthcare professionals and patients. The model's development involved the meticulous processing of high-quality sources, including reputable medical websites, renowned medical textbooks, and peer-reviewed research papers. This ensures that the language used in test descriptions is not only accurate and informative but also up-to-date with the latest medical findings and trends. By leveraging this rich tapestry of trusted sources, our AI system provides a deeper understanding of each test, fostering informed decision-making and enhanced patient care.
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