The HLA DQ2/DQ8 lab test is a genetic analysis designed to assess an individual's risk for celiac disease, an autoimmune disorder triggered by gluten consumption that damages the small intestine. This test identifies specific genetic markers, particularly the HLA-DQ2 and HLA-DQ8 alleles, which are strongly associated with celiac disease. Approximately 90% of celiac patients carry the HLA-DQ2 haplotype, while 5-10% have the HLA-DQ8 haplotype. The test involves extracting DNA from a blood sample and using real-time PCR technology to detect the presence of these alleles. Results can indicate a genetic predisposition to celiac disease, with a significantly higher risk for those carrying these haplotypes. However, the presence of these genetic markers alone does not confirm the disease, as other genetic and environmental factors also contribute. The test is valuable for ruling out celiac disease in individuals without these haplotypes and aids in tailoring diagnostic and treatment strategies.
The HLA DQ2/DQ8 lab test is a genetic analysis designed to assess an individual's risk for celiac disease, an autoimmune disorder triggered by gluten consumption that damages the small intestine. This test identifies specific genetic markers, particularly the HLA-DQ2 and HLA-DQ8 alleles, which are strongly associated with celiac disease. Approximately 90% of celiac patients carry the HLA-DQ2 haplotype, while 5-10% have the HLA-DQ8 haplotype. The test involves extracting DNA from a blood sample and using real-time PCR technology to detect the presence of these alleles. Results can indicate a genetic predisposition to celiac disease, with a significantly higher risk for those carrying these haplotypes. However, the presence of these genetic markers alone does not confirm the disease, as other genetic and environmental factors also contribute. The test is valuable for ruling out celiac disease in individuals without these haplotypes and aids in tailoring diagnostic and treatment strategies.
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The HLA DQ2/DQ8 lab test is a genetic analysis used to assess the risk of celiac disease by identifying specific genetic markers. This test focuses on detecting HLA-DQ2 and HLA-DQ8 alleles, which are strongly associated with celiac disease.
- DNA Extraction: Blood sample DNA is extracted.
- PCR Amplification: DNA is amplified to generate specific sequences.
- Probe Hybridization: TaqMan probes bind to DQA1 and DQB1 alleles.
- Detection: Presence of probes indicates specific alleles.
- Result Interpretation: Determines presence or absence of DQ2/DQ8 haplotypes.
Understanding these markers aids in managing celiac disease risk.
Plasma viscosity testing is essential for individuals with conditions that affect plasma protein levels. Key groups who should be tested include:
- Patients with Inflammatory Diseases: Conditions like rheumatoid arthritis often elevate plasma viscosity. Regular testing helps monitor disease severity and treatment efficacy.
- Individuals with Malignant Disorders: Diseases such as multiple myeloma can cause significant increases in plasma viscosity due to paraprotein secretion.
- Those with Hyperviscosity Syndrome: Monitoring is crucial for managing symptoms and treatment response, particularly in cases involving IgM monoclonal proteins.
This test is invaluable for assessing acute phase responses and ensuring effective clinical management.
Understanding test results from the HLA DQ2/DQ8 lab test is crucial for assessing genetic risk for celiac disease. Here's a brief guide:
- Negative Result: Absence of DQ2/DQ8 haplotypes suggests a low likelihood of developing celiac disease.
- Positive Result: Presence of DQ2 and/or DQ8 indicates a genetic predisposition, increasing risk significantly.
- Half DQ2: Detection of only one allele (HLA-DQA1*05 or HLA-DQB1*02) suggests a lower, yet elevated risk.
While these results highlight genetic risk, they don't confirm celiac disease, necessitating further clinical evaluation.
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