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Horseradish IgG

Horseradish IgG

The Islet Antigen 2 (IA2) antibody test is a crucial diagnostic tool for detecting autoantibodies against the tyrosine phosphatase-related islet antigen 2 in human serum. These autoantibodies are significant markers for autoimmune diabetes, particularly type 1 diabetes. The test aids clinicians in distinguishing between type 1 and type 2 diabetes, identifying individuals at risk of developing type 1 diabetes, and predicting the future need for insulin therapy in adult-onset diabetes patients. Utilizing a quantitative Enzyme-Linked Immunosorbent Assay (ELISA), the test measures IA2 antibody levels, with results indicating a positive presence at concentrations typically above 7.5 Units/mL. While a positive result supports a diagnosis of type 1 diabetes and suggests a higher risk of future insulin dependency, negative results do not entirely rule out the disease. The IA2 antibody test is often part of a broader panel, including other autoantibodies like GAD65 and ZnT8, to provide a comprehensive assessment of autoimmune diabetes risk.

Price of test:£34

The lowest price from the last 30 days: £34

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The IA2 antibody test is crucial for distinguishing between type 1 and type 2 diabetes. It helps identify individuals at risk of developing type 1 diabetes and predicts future insulin needs. Key points include:

- Purpose: Differentiates autoimmune diabetes from metabolic disorders.
- Specimen: Requires serum; proper handling is essential.
- Methodology: Uses ELISA for detection.
- Interpretation: Positive results indicate a higher risk for type 1 diabetes.
- Limitations: Negative results don't rule out future risk.
- Clinical Contexts: Useful for high-risk individuals and predicting insulin therapy needs.

Who Should Get Tested

Horseradish peroxidase (HRP)-conjugated antibodies are vital in laboratory settings for detecting specific proteins. These antibodies, targeting IgG, are used in:

- Immunohistochemistry (IHC): Detects proteins in tissue sections, aiding disease diagnosis.
- Western Blotting: Identifies proteins by size, confirming their presence in samples.
- ELISA: Quantifies proteins or antibodies in samples using colorimetric detection.

HRP catalyzes substrate oxidation, producing a visible color change proportional to protein presence. These antibodies are species-specific, minimizing cross-reactivity, and are stored at low temperatures to maintain stability.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for the IA2 antibody test is crucial for effective diabetes management. Here's a brief guide:

- Positive Result: Indicates the presence of IA2 autoantibodies, suggesting a strong likelihood of type 1 diabetes or increased risk of developing it.
- Negative Result: Does not rule out type 1 diabetes; further testing may be needed.
- Clinical Implications: Positive results may predict future insulin therapy needs.
- Reference Ranges: Typically, ≥7.5 Units/mL is positive, but ranges may vary by lab.

Understanding these results aids in distinguishing diabetes types and planning treatment.

Price of test:£34

The lowest price from the last 30 days: £34

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