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Procollagen 1 Pept (N-Terminal)

Procollagen 1 Pept (N-Terminal)

The Procollagen III Peptide (P3NP) test is a non-invasive serum-based assay designed to monitor liver fibrosis and cirrhosis, especially in patients undergoing long-term methotrexate therapy for conditions like psoriasis. This test measures the amino terminal of type III procollagen, a marker released during collagen synthesis, which is heightened in fibrotic conditions. Elevated P3NP levels in the serum suggest increased collagen turnover, a key indicator of liver fibrosis. The liver, being a primary site for collagen synthesis, makes P3NP levels particularly relevant for assessing liver health. In methotrexate therapy, the P3NP test aids in evaluating the risk of liver fibrosis, potentially reducing the need for invasive liver biopsies. While effective, the test's limitations include elevated levels in non-liver conditions and less reliability in pediatric patients due to growth-related collagen turnover. Despite these, the P3NP test remains a crucial tool in the early detection and management of liver fibrosis.

Price of test:£348

The lowest price from the last 30 days: £348

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The Procollagen III Peptide (P3NP) test is a non-invasive serum assay for detecting liver fibrosis, especially in patients on long-term methotrexate therapy. It measures collagen turnover, crucial in fibrotic conditions. Key points include:

- Mechanism: P3NP indicates collagen synthesis, elevated in liver fibrosis.
- Application: Monitors methotrexate-induced liver damage, reducing biopsy need.
- Protocol: Serial measurements guide clinical decisions.
- Limitations: Elevated levels can occur in non-liver conditions.
- Practicality: Requires minimal serum, quick results.
- Reference Range: 1.2-4.2 μg/L; >8 μg/L suggests fibrosis risk.

This test aids in early detection and management of liver fibrosis.

Who Should Get Tested

The Procollagen 1 N-Terminal Peptide (P1NP) test is essential for evaluating bone formation. It is particularly useful for:

- Monitoring Osteoporosis Treatments:
- Teriparatide therapy increases P1NP levels, indicating enhanced bone formation.
- Bisphosphonates decrease P1NP levels, reflecting reduced bone resorption.

- Specimen Handling:
- Serum samples are collected in red-top tubes.
- Consistent collection times minimize diurnal variation.

- Interpreting Results:
- Reference ranges vary by age and gender.
- A ≥21% change from baseline indicates treatment response.

The P1NP test is crucial for managing osteoporosis but not for general screening.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for the Procollagen III Peptide (P3NP) test involves interpreting serum levels to assess liver fibrosis risk. Key points include:

- Elevated P3NP Levels: Indicate increased collagen synthesis, a marker of liver fibrosis.
- Reference Range: Normal levels are 1.2–4.2 μg/L; levels above 8 μg/L suggest fibrosis.
- Clinical Context: Consider other conditions like bone fractures that may elevate P3NP.
- Pediatric Considerations: Growth can affect levels, requiring careful interpretation.
- Sample Collection: Requires 250 μL serum, with results in 24 hours for out-patients.

Understanding these aspects aids in effective clinical decision-making.

Price of test:£348

The lowest price from the last 30 days: £348

AI-Powered Insights and Expert Validation

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