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Thiopurine Methyl Transferase

Thiopurine Methyl Transferase

The Tramadol and Metabolite, Random Urine test is a laboratory procedure designed to detect tramadol and its active metabolite, O-desmethyltramadol, in urine. This test is primarily used to monitor compliance with tramadol therapy and identify illicit use. Utilizing Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS), the test involves adding isotopically labeled standards to the urine sample, which is then analyzed to quantify the presence of tramadol and its metabolite. A random urine specimen of at least 1 mL is required, collected without preservatives. The specimen remains stable for up to 14 days at room temperature, refrigerated, or frozen. A positive result is indicated by levels of 25 ng/mL or higher. While the test provides crucial insights for healthcare professionals, it is not suitable for forensic purposes. The turnaround time ranges from 2 to 6 days, depending on various factors. This test aids in ensuring effective patient care by accurately detecting tramadol use.

Price of test:£188

The lowest price from the last 30 days: £188

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The Tramadol and Metabolite, Random Urine test is a laboratory analysis designed to detect tramadol and its metabolite, O-desmethyltramadol, in urine. It is used for:

- Monitoring compliance with tramadol therapy
- Detecting illicit tramadol use

Methodology:

- Utilizes LC-MS/MS
- Involves isotopically labeled standards

Specimen Requirements:

- Random urine specimen
- Minimum volume: 1 mL

Interpretation:

- Levels ≥25 ng/mL indicate tramadol use
- Not for therapeutic drug management

This test aids healthcare professionals in managing patient care effectively.

Who Should Get Tested

Thiopurine Methyltransferase (TPMT) testing is crucial for patients prescribed thiopurine drugs, used in treating autoimmune diseases, inflammatory bowel disease, and more. Key points include:

- Normal Activity: Indicates low risk of myelosuppression; standard doses are generally safe.
- Low Activity: High risk of myelosuppression; thiopurine drugs should be avoided.
- Intermediate Activity: Requires dose adjustment and monitoring.

Testing involves measuring TPMT activity in red blood cells. Considerations include avoiding blood transfusions and certain medications before testing. This ensures accurate results, guiding safe and effective treatment.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results is crucial for effective patient care. Here's a brief guide:

- Positive Result: Indicates tramadol use if levels are ≥25 ng/mL.
- Negative Result: May suggest non-compliance or improper specimen collection.
- Limitations: Urine levels don't correlate with serum levels; not for therapeutic management.
- Interpretation: Should be done by healthcare professionals.
- Turnaround Time: Typically 2-6 days, subject to lab conditions.

This test aids in monitoring tramadol therapy compliance and detecting misuse, ensuring informed clinical decisions.

Price of test:£188

The lowest price from the last 30 days: £188

AI-Powered Insights and Expert Validation

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