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Whipples Disease (PCR)

Whipples Disease (PCR)

The Wheat IgG test is a diagnostic tool designed to evaluate the immune system's response to wheat proteins by measuring IgG antibodies. IgG, the most prevalent antibody type in the blood, plays a vital role in neutralizing pathogens. This test is part of a broader category of immunoglobulin tests used to identify food sensitivities and intolerances, particularly to wheat and gluten. The procedure involves analyzing a blood sample for IgG antibodies targeting wheat proteins, typically using an enzyme-linked immunosorbent assay (ELISA). Elevated IgG levels suggest a sensitivity to wheat, often linked to digestive enzyme deficiencies, leading to an immune response against undigested proteins. Unlike a wheat allergy, which triggers immediate and severe reactions, wheat sensitivity results in milder symptoms like bloating and abdominal discomfort. While the test provides insights into wheat sensitivity, it is not a definitive diagnostic tool for celiac disease or autoimmune disorders, necessitating professional interpretation and guidance.

Price of test:£419

The lowest price from the last 30 days: £419

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The Wheat IgG test evaluates the immune response to wheat proteins by measuring IgG antibodies. This test helps identify sensitivities and intolerances, offering insights into potential dietary adjustments. Key points include:

- IgG Role: IgG antibodies neutralize pathogens and indicate food sensitivities.
- Test Process: Involves blood sampling and analysis using ELISA.
- Results Interpretation: High IgG levels suggest sensitivity, not necessarily an allergy.
- Management: A wheat-free diet may alleviate symptoms.
- Limitations: Not a definitive diagnostic tool; consult healthcare providers for comprehensive evaluation.

Who Should Get Tested

Whipple's disease, caused by *Tropheryma whipplei*, requires precise diagnostic methods due to its systemic impact. PCR testing is crucial for detecting the bacterium in various specimens. Key specimens include:

- Whole Blood: Collected in EDTA tubes, refrigerated or frozen.
- Cerebrospinal Fluid (CSF): Transferred to sterile containers.
- Tissue: Fresh samples from affected organs.
- Saliva and Stool: Useful when other samples are unavailable.

PCR involves DNA extraction, amplification, and detection, offering high sensitivity and specificity. Despite its utility, PCR has limitations, such as contamination risks and inability to distinguish active from latent infections.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results is crucial for managing wheat sensitivities. The Wheat IgG test measures IgG antibodies to wheat proteins, indicating potential sensitivities. Here's a brief overview:

- IgG Antibodies: Common in blood, they help identify food sensitivities.
- Test Process: Involves a blood sample analyzed for IgG levels.
- Results Interpretation: High IgG suggests sensitivity, not necessarily an allergy.
- Management: A wheat-free diet may alleviate symptoms.
- Limitations: Not definitive for diagnosing celiac disease; consult healthcare providers for comprehensive evaluation.

Price of test:£419

The lowest price from the last 30 days: £419

AI-Powered Insights and Expert Validation

Advanced AI Interpretation

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At the core of Diagu's AI system is an advanced language model, engineered to transform complex medical data into clear, comprehensible, and informative descriptions. This model is adept at articulating detailed test analyses in a way that is accessible to both healthcare professionals and patients. The model's development involved the meticulous processing of high-quality sources, including reputable medical websites, renowned medical textbooks, and peer-reviewed research papers. This ensures that the language used in test descriptions is not only accurate and informative but also up-to-date with the latest medical findings and trends. By leveraging this rich tapestry of trusted sources, our AI system provides a deeper understanding of each test, fostering informed decision-making and enhanced patient care.

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