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  4. Liver Function Test (LFT): High Bilirubin Levels Explained

Liver Function Test (LFT): High Bilirubin Levels Explained

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High bilirubin levels in a liver function test (LFT) indicate potential liver dysfunction or other underlying health issues. Bilirubin is a yellow pigment produced during the breakdown of red blood cells. When the liver isn’t functioning properly, bilirubin builds up in the blood, leading to jaundice (yellowing of the skin and eyes). Elevated bilirubin may signal conditions such as liver disease, bile duct obstruction, or hemolytic anemia. Treatments focus on addressing the underlying cause, such as improving liver function, treating infections, or removing blockages in the bile duct.

High bilirubin levels revealed in a liver function test (LFT) can have several underlying causes and health implications. Bilirubin is a byproduct of red blood cell breakdown, and the liver’s role is to process and excrete it. When bilirubin levels rise, it may indicate liver dysfunction or other health concerns.

  • Potential Causes of High Bilirubin:
    • Liver Disease: Conditions like hepatitis, cirrhosis, or fatty liver disease can impair the liver’s ability to process bilirubin, leading to an increase in levels.
    • Bile Duct Obstruction: Gallstones or tumors can block bile ducts, preventing bilirubin from being excreted properly.
    • Hemolytic Anemia: This condition causes the rapid breakdown of red blood cells, overwhelming the liver’s capacity to handle bilirubin.
    • Inherited Disorders: Conditions such as Gilbert’s syndrome can lead to intermittent elevations in bilirubin without liver damage.
  • Health Implications:
    • Jaundice: High bilirubin levels cause yellowing of the skin and eyes, which is a visible symptom of jaundice.
    • Liver Dysfunction: Prolonged elevated bilirubin levels can signal worsening liver health and require immediate attention.
    • Risk of Further Complications: Untreated high bilirubin can lead to chronic liver disease or systemic complications like cholestasis (bile flow obstruction).
  • Treatment Options:
    • Addressing Underlying Causes: Treating liver infections, managing hemolysis, or surgically removing bile duct obstructions can lower bilirubin levels.
    • Lifestyle Changes: Reducing alcohol consumption, improving diet, and maintaining a healthy weight can support liver function.

Recommended Tests:

  1. Alanine Aminotransferase (ALT) Test:
    Measures liver enzyme levels to evaluate liver inflammation or damage, often elevated with high bilirubin.
    ALT Test
  2. Total Bilirubin Test:
    A direct measure of the bilirubin in your blood, this test helps determine the severity of jaundice or liver dysfunction.
    Total Bilirubin Test

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