Depression is a significant global health issue, affecting millions of individuals across diverse demographics. Characterized by persistent sadness, loss of interest in daily activities, and a range of physical and emotional problems, depression can severely impair one’s ability to function at work and in personal life. According to the World Health Organization, depression is a leading cause of disability worldwide and a major contributor to the overall global burden of disease. Given its prevalence and impact, accurate diagnosis is crucial for effective treatment. Misdiagnosis or delayed diagnosis can lead to inadequate treatment, prolonged suffering, and a higher risk of complications, including suicide. Therefore, the development of reliable diagnostic tools, including the potential use of blood tests, is essential to improve outcomes for individuals suffering from depression. Understanding and utilizing advanced diagnostic methods can pave the way for more personalized and effective treatment strategies.